Discovering molecular pathways underlying healthy ageing for prevention, diagnosis, and treatment.

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AwE Publications

Healthspan Pathways

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News

AwE contributes a talk and a poster at
"Undoing Aging 2018" in March in Berlin, Germany.

AwE presents a poster at "Pushing the Limits of Healthspan and Longevity" in April 2018 in Hanover, Germany.

Ageing with elegans: a research proposal to map healthspan pathways
Biogerontology. 2016 Apr 4.

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Anti-aging pharmacology: Promises and pitfalls
Anti-Aging Reviews November 2016

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DNA methylation-based measures of biological age: meta-analysis predicting time to death
Aging September 2016

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Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7
Aging Aug 2016

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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
eLife Aug 2016

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Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription
Science Advanced Juli 2016

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Cellular senescence: Implications for metabolic disease
Molecular and Cellular Endocrinology Aug 2016

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Special edition Journal of Gerontology: Moving Geroscience into Uncharted Waters
Journal of Biogerontology Aug 2016.

NEW publication: A nutritional supplement containing lactoferrin stimulates the immune system, extends lifespan, and reduces amyloid β peptide toxicity in Caenorhabditis elegans
Food Science & Nutrition July 2016.

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NEW publication: Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
Nature July 2016.

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NEW publication: Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity
Experimental Gerontology September 2016.

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NEW publication: Dietary Protein, Metabolism, and Aging
June 2016 .

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NEW publication: ‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
2016 May 10.

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NEW publication: Chemical activation of a food deprivation signal extends lifespan
2016 May 24.

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NEW publication: Does Longer Lifespan Mean Longer Healthspan?
2016 May 27.

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NEW publication: Geroscience approaches to increase healthspan and slow aging
F1000 Faculty Reviews. 2016 Apr 29.

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NEW publication: NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Science. 2016 Apr 28.

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NEW publication: Whole-Genome Sequencing of a Healthy Aging Cohort
Cell. 2016 Apr 21.

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NEW publication: Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes
Oncotarget. 2016 Feb 24.

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NEW publication: Novel loci and pathways significantly associated with longevity
Nature. 2016 Jan 20.

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NEW Publication: Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
Cell Reports Apr 8

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NEW Publication: Destroying worn-out cells makes mice live longer
Ageing: Out with the old
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan Nature, February 3, 2016

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NEW Publication: The temporal scaling of Caenorhabditis elegans ageing Nature, January 27, 2016

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The scientific quest to cure aging CBS News, January 27, 2016

Publication: A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell, December 16, 2015

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Publication: Measures of Healthspan as Indices of Aging in
Mice—A Recommendation Cell Metabolism, December 10, 2015

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Publication: Mitochondrial Dysfunction Induces Senescence with
a Distinct Secretory Phenotype Cell Metabolism, February 9, 2016.

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Publication: Healthy aging: The ultimate preventative medicine Science, December 4, 2015.

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Publication: Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin The Journal of Neuroscience, September 16, 2015.

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Publication: An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans Bioenergetics, November 2015

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Publication: A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology 2015, 16:185

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Publication: Genetics and Pharmacology of Longevity: The Road to Therapeutics for Healthy Aging Advances in Genetics, 2015

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Publication: Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians EBioMedicin, 22 July 2015

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Publication: β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis Nature Medecin August 2015

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Publication: A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism 7 July 2015

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Publication: Quantification of biological aging in young adults. PNAS 6 July 2015

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Publication: Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. J Gerontolog A Biol Sci Med Sci 10 March 2015

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Events

AwE presented at the online “Aging Summit” in February 2018,
on “Healthspan, Lifespan and Well-being: Definitions and Pathways”.

IUBMB Focused Meeting on «Molecular aspects of aging and longevity»
September 16-19, 2017
Athens, Greece

The Future of Aging: IAGG-ER’s 10th European Congress of Biogerontology.
Chairman of the Biological Section: Suresh Rattan
September 23-24, 2016
Nencki Institute, Warsaw, Poland
Flyer.

First International Symposium Research on Healthy Ageing
December 8-9, 2016, Grand Palais, Lille, France.
Flyer.

The 2nd edition of the International Symposium entitled Biology of Aging: Paving the way for healthy aging.
Wednesday, October 19 and Thursday, October 20, 2016.
Montreal, Quebec, Canada.

International Conference on Aging and Disease of the International Society on Aging and Disease
October 1-2, 2016
Stanford University, California, United States

Past events:

45th Annual Conference of the American Aging Association. Targeting Aging: the Ultimate Preventative Medicine
June 1-2, 2016
Bell Harbor Conference Center, Seattle, USA

Conference of the Calorie Restriction Society International
May 18-21, 2016
University of Arizona, AZ, USA

Oxygen Club of California 2016 World Congress: “Redox Medicine and Nutrition”.
May 4-6, 2016
Department of Nutrition, University of California, Davis
Confirmed Program HERE.

Disease Drivers of Aging: 2016 Advances in Geroscience Summit
April 13 – 14, 2016
The New York Academy of Sciences, NY, USA

Death, Aging and Healthspan: From Definitions to Data Semantics
Rostock, 26.-27. November 2015, Thursday afternoon 16h until Friday afternoon 16h.

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