WP3 – C. elegans healthspan
Taking advantage of the WorMotel setup (developed at Fang-Yen lab), we follow up life trajectories of individual animals, evaluating their locomotion as a proxy for general health at each day of their adult life. Out of the results of an RNAi-based screen, genetic modifiers of a disproportionate health/lifespan are selected for in-depth evaluation. Reporter panels and omics analyses assist in the grouping of healthspan-modifying interventions and reveal relevant molecular changes. Other phenotypic readouts, such as age-related neuronal function or pathogen resistance, are evaluated as well. Taken together, these experiments provide a complete platform for screening ánd in-depth study of healthspan using the model system C. elegans.